We study D- and c-optimal designs for dose-finding with opposing failure functions. In particular, we study the contingent response models of Li, Durham and Flournoy (1995). In the contingent response model, there are two ...

We study D- and c-optimal designs for the contingent response models of (1995). In the contingent response model there are two types of failure. We call one failure type toxicity and the other disease failure. No toxicity ...