Now showing items 1-10 of 12
Optimal designs for dose-finding in contingent response models
(University of Missouri--Columbia, 2004-12)
We study D- and c-optimal designs for dose-finding with opposing failure functions. In particular, we study the contingent response models of Li, Durham and Flournoy (1995). In the contingent response model, there are two ...
Differential expression of BRCC2, a novel BH3-like domain-containing apoptotic molecule, in ductal versus lobular breast carcinoma
(American Association for Cancer Research, 2007)
Background: BRCC2 (breast cancer cell 2) gene was discovered as an approximately 1.2 kb transcript in MDA-MB 231 human breast cancer cells (GenBank accession numbers AF220061 and AF303179). BRCC2 is a 12 kDa cytosolic ...
Optimal designs for contingent response models
We study D- and c-optimal designs for the contingent response models of (1995). In the contingent response model there are two types of failure. We call one failure type toxicity and the other disease failure. No toxicity ...
Preparation of Novel Cyanoguanidine Derivatives of Tryptamines
A new class of cyanoguanidine derivatives bearing a tryptamine moiety was prepared by a three-step reaction sequence. The preparation of the starting materials and characterization of the intermediates are also described.
The Clinical Utility of Y-PSMA2 Monoclonal Antibody in the Detection of Primary and Peripheral Blood Metastatic Prostate Cancer
(Pluto Journals, 2006)
The monoclonal antibody 7E11-C5.3 was the first anti-PSMA antibody to be developed. It recognizes a PSMA intracellular epitope, is radio-labeled and used to detect early recurrent and metastatic prostate cancer. The ...
Making a friend from a foe: expressing a GroEL gene from the whitefly Bemisia tabaci in the phloem of tomato plants confers resistance to tomato yellow leaf curl virus
(Archives of Virology, 2007-03-05)
Some (perhaps all) plant viruses transmitted in a circulative manner by their insect vectors avoid destruction in the haemolymph by interacting with GroEL homologues, ensuring transmission. We have previously shown that ...